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It has since been studied extensively and, although it is inherently poisonous, it is now used for a wide spectrum of medical ailments. It was also used by Cleopatra and women in the Renaissance era to dilate their pupils to give them a more beautiful appearance. Its first recorded use was in the 4th year of B.C.E, where it was used to treat wounds, gout, sleeplessnes, and was even thought to be a love potion. Īs a plant compound, Atropine has been used for hundreds of years.
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In humans, atropine is metabolized approximately 50%, hydrolyzed to tropine and toropic acid, and the remaining unchanged drug is excreted in the urine. It is a competitive antagonist of both acetylcholine receptors and phospholipase 2A and has a variety of effects on both humans and animals. It's chemical name is 8-methyl-8-azabicycolooct-3-yl) 3-hydroxy-2-phenylpropanoate, and the most common medicinal form of atropine is atrophine sulfate ((C17H23NO3)2 Atropine is an alkaloid drug derived from levohyscocyamine, a plant compound found in the family Solanaceae.
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